Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations
Age-related clonal expansion of cells harbouring mosaic chromosomal alterations (mCAs) is
one manifestation of clonal haematopoiesis. Identifying factors that influence the generation …
one manifestation of clonal haematopoiesis. Identifying factors that influence the generation …
Clonal hematopoiesis due to mosaic chromosomal alterations: Impact on disease risk and mortality
Mosaic chromosomal alterations (mCAs) are the clonal expansion of large somatically
acquired structural chromosomal changes present on the autosomes and sex …
acquired structural chromosomal changes present on the autosomes and sex …
[HTML][HTML] Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in …
Background Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …
Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism, yet our knowledge of the causes and consequences of this is …
form of clonal mosaicism, yet our knowledge of the causes and consequences of this is …
[HTML][HTML] Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
[HTML][HTML] Genetics of smoking and risk of clonal hematopoiesis
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing …
alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing …
Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations
YA Jakubek, AP Reiner, MC Honigberg - Translational Research, 2023 - Elsevier
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …
CHIP is associated with cardiovascular disease in the UK Biobank
Clonal hematopoiesis (CH) is a form of age-related somatic mosaicism. CH encompasses
both clonal events with recognizable leukemic driver mutations, such as CH of indeterminate …
both clonal events with recognizable leukemic driver mutations, such as CH of indeterminate …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Genetics of autosomal mosaic chromosomal alteration (mCA)
Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are
regarded as one of the common features of cancers. Strikingly, accumulating studies …
regarded as one of the common features of cancers. Strikingly, accumulating studies …