Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers
for a host of human diseases. Here, to gain a better understanding of mCA rates in …

Background: Cancer survivors are at an increased risk of cardiovascular disease (CVD)
compared with the general population. We sought to evaluate the impact of mosaic …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …

Mosaic chromosomal alterations (mCAs) in hematopoietic cells increase mortality and risk of
hematological cancers and infections. We investigated the landscape of mCAs and their …

Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …

Mosaic chromosomal alterations (mCAs) are common in cancers and can arise decades
before diagnosis. A quantitative understanding of the rate at which these events occur, and …

Hematopoietic stem and progenitor cells (HSPCs) gradually accumulate DNA mutations
during a lifespan, which can contribute to age-associated diseases such as leukemia …

Aging is characterized by increased mortality, functional decline, and exponential increases
in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological …

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …