Clonal hematopoiesis (CH) is a prevalent condition that results from somatic mutations in
hematopoietic stem cells. When these mutations occur in “driver” genes, they can potentially …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

Large copy-number variants (CNVs) are strongly associated with both developmental delay
and cancer, but the type of disease depends strongly on when and where the mutation …

Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …

Recent genomics studies have revealed that clonal hematopoietic expansion due to
recurrent somatic mutations in hematopoietic cells are common in older people without …

Abstract Background Clonal chromosomal alterations (CCAs) reflect recurrent genetic
changes derived from a single evolving clone, whereas nonclonal chromosomal alterations …

Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent
overrepresentation of cells from a common stem/progenitor lineage harboring single …

Introduction: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a pre-cancerous
age-associated condition characterized by somatic mutations (typically in DNMT3A, TET2 …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Detectable clonal mosaicism for large chromosomal events has been associated with aging
and an increased risk of hematological and some solid cancers. We hypothesized that …