Clonal hematopoiesis (CH), in which hematopoietic stem and progenitor cell (HSPC) clones
and their progeny expand in the circulating blood cell population, occurs following the …

Introduction: Somatic mutations accrue in hematopoietic stem cells with age and can lead to
selective clonal expansion, a process termed Clonal Hematopoiesis of Indeterminate …

Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …

Large copy-number variants (CNVs) are strongly associated with both developmental delay
and cancer, but the type of disease depends strongly on when and where the mutation …

Human cells acquire somatic mutations throughout life, some of which can drive clonal
expansion. Such expansions are frequent in the hematopoietic system of healthy individuals …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP)/age-related CH is a new
phenomenon of aging that affects a large proportion (> 10%) of older adults. CH arises upon …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent
overrepresentation of cells from a common stem/progenitor lineage harboring single …

Recent genomics studies have revealed that clonal hematopoietic expansion due to
recurrent somatic mutations in hematopoietic cells are common in older people without …

Abstract Background Clonal chromosomal alterations (CCAs) reflect recurrent genetic
changes derived from a single evolving clone, whereas nonclonal chromosomal alterations …