Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an
acquired genetic variant, emerges with age. Although in general CH is associated with …

Highlights•Clonal hematopoiesis (CH) is associated with atherosclerosis, heart failure, and
stroke.•Common risk factors prompt CH, cancer, and cardiovascular diseases …

Loss of stem cell regenerative potential underlies aging of all tissues. Somatic mosaicism,
the emergence of cellular patchworks within tissues, increases with age and has been …

Highlights•Environmental factors influence the development of clonal hematopoiesis.•
Inflammation exerts a strong influence on hematopoietic stem cell biology and may serve as …

Clonal hematopoiesis results from somatic mutations in hematopoietic stem cells, which give
an advantage to mutant cells, driving their clonal expansion and potentially leading to …

Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the presence of
myeloid cancer-associated, somatic mutations with a variant allele frequency (VAF) of≥ 2 …

Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate
system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age …

Recent large cohort studies revealed that healthy older individuals harbor somatic mutations
that increase their risk for hematologic malignancy and all-cause cardiovascular deaths. The …

There are increasing evidences showing the contribution of somatic genetic variants to non-
cancer diseases. However, their detection using massive parallel sequencing methods still …

Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation
process. To characterize the transition of BC into PC, transcriptomes from human naïve BC …