The clinical management of clonal hematopoiesis: creation of a clonal hematopoiesis clinic

KL Bolton, A Zehir, RN Ptashkin… - Hematology …, 2020 - hemonc.theclinics.com
Hematol Oncol Clin N Am 34 (2020) 357–367 https://doi. org/10.1016/j. hoc. 2019.11. 006
hemonc. theclinics. com 0889-8588/20/© 2019 Elsevier Inc. All rights reserved. phenotype …

Clonal dominance of a donor‐derived del (20q) clone after allogeneic hematopoietic stem cell transplantation in an acute myeloid leukemia patient with del (20q)

J Yoon, JW Yun, CW Jung, HJ Kim… - Journal of Clinical …, 2019 - Wiley Online Library
Del (20q) is the most frequently detected large structural genetic mosaicism alteration in the
healthy aging population, occurring in approximately 0.1% of older persons. Age‐related …

[HTML][HTML] Genetic Predisposition to Clonal Hematopoiesis

PM Quiros, GS Vassiliou - Hemasphere, 2023 - journals.lww.com
Clonal hematopoiesis (CH), the clonal expansion of a hematopoietic stem cell (HSC) and its
progeny driven by somatic mutations, is a common phenomenon that becomes …

Reply to 'Mosaic loss of chromosome Y in leukocytes matters'

W Zhou, MJ Machiela, ND Freedman, N Rothman… - Nature …, 2019 - nature.com
Zhou et al. reply—A revised Correspondence by Forsberg et al. 1 (whose authors include
the founders of CRAY Innovation, LA Forsberg and JP Dumanski) posits that the …

Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway Activation

JB Heimlich, P Bhat, AC Parker, MT Jenkins… - Blood Advances, 2024 - Elsevier
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for
hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk …

[HTML][HTML] Detection and characterization of male sex chromosome abnormalities in the UK Biobank study

Y Zhao, EJ Gardner, MA Tuke, H Zhang, M Pietzner… - Genetics in …, 2022 - Elsevier
Purpose The study aimed to systematically ascertain male sex chromosome abnormalities,
47, XXY (Klinefelter syndrome [KS]) and 47, XYY, and characterize their risks of adverse …

The lifelong natural history of clonal hematopoiesis and its links to myeloid neoplasia

MA Fabre, GS Vassiliou - Blood, 2024 - ashpublications.org
The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …

Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseases

M Ono, RJ Tanaka, M Kano, T Sugiman - PloS one, 2013 - journals.plos.org
The understanding of pathological processes is based on the comparison between
physiological and pathological conditions, and transcriptomic analysis has been extensively …

[HTML][HTML] Clonal haematopoiesis is not prevalent in survivors of childhood cancer

G Collord, N Park, M Podestà, M Dagnino… - British Journal of …, 2018 - ncbi.nlm.nih.gov
Clonal haematopoiesis driven by leukaemia-associated somatic mutations is a common
feature of ageing (Link & Walter, 2016). This phenomenon, termed clonal haematopoiesis of …

Genomic copy number variation affecting genes involved in the cell cycle pathway: implications for somatic mosaicism

IY Iourov, SG Vorsanova, MA Zelenova… - … Journal of Genomics, 2015 - Wiley Online Library
Somatic genome variations (mosaicism) seem to represent a common mechanism for
human intercellular/interindividual diversity in health and disease. However, origins and …