Synthetic Polymers as Drug‐Delivery Vehicles in Medicine
EW Neuse - Metal‐Based Drugs, 2008 - Wiley Online Library
Cancerous diseases present a formidable health problem worldwide. While the
chemotherapy of cancer, in conjunction with other treatment modalities, has reached a …
chemotherapy of cancer, in conjunction with other treatment modalities, has reached a …
Drug-polymer conjugates: potential for improved chemotherapy
R Duncan - Anti-cancer drugs, 1992 - journals.lww.com
Use of polymeric drug delivery systems is rapidly becoming an established approach for
improvement of cancer chemotherapy. Zoladex (R), a poly lactide-co-glycolide …
improvement of cancer chemotherapy. Zoladex (R), a poly lactide-co-glycolide …
Macromolecular antiproliferative agents featuring dicarboxylato-chelated platinum
LL Komane, EH Mukaya, EW Neuse… - Journal of Inorganic and …, 2008 - Springer
Cancerous diseases, together with cardiac afflictions, account for the predominant causes of
death among the adult population of the Western world. The classical platinum drugs, with …
death among the adult population of the Western world. The classical platinum drugs, with …
Synthesis and preliminary in vitro evaluation of polymeric dicarboxylato‐ and dihydroxylatoplatinum(II) chelates as antiproliferative agents
EW Neuse, N Mphephu… - Polymers for …, 2002 - Wiley Online Library
Despite much progress in the chemotherapy of cancerous diseases, antitumor drugs in
current clinical use suffer from major pharmacological deficiencies. The platinum drug …
current clinical use suffer from major pharmacological deficiencies. The platinum drug …
Polymer-drug conjugates: Novel carriers for cancer chemotherapy
Cancer is the second worldwide cause of death following cardiovascular diseases.
Chemotherapy is the gold standard strategy for effective treatment of cancer. However, the …
Chemotherapy is the gold standard strategy for effective treatment of cancer. However, the …
Polymer conjugates: nanosized medicines for treating cancer
MJ Vicent, R Duncan - Trends in biotechnology, 2006 - cell.com
Interdisciplinary research at the interface of polymer chemistry and the biomedical sciences
has produced the first polymer-based nanomedicines for the diagnosis and treatment of …
has produced the first polymer-based nanomedicines for the diagnosis and treatment of …
Combination therapy: opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines
The discovery of new molecular targets and the subsequent development of novel
anticancer agents are opening new possibilities for drug combination therapy as anticancer …
anticancer agents are opening new possibilities for drug combination therapy as anticancer …
Macromolecule-drug conjugates in targeted cancer chemotherapy.
H Sezaki, M Hashida - Critical reviews in therapeutic drug carrier …, 1984 - europepmc.org
Although clinical trials using macromolecular conjugates of cytotoxic drugs in a treatment of
malignant disease are fragmentary at best, a number of carrier systems that have been …
malignant disease are fragmentary at best, a number of carrier systems that have been …
[图书][B] Polymer therapeutics for cancer: current status and future challenges
R Satchi-Fainaro, R Duncan, CM Barnes - 2006 - Springer
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery
systems have improved the efficacy and reduced the toxicity of current therapies and …
systems have improved the efficacy and reduced the toxicity of current therapies and …
Polymer conjugates with anticancer activity
D Putnam, J Kopeček - Biopolymers Ii, 2005 - Springer
Polymer conjugates may possess anticancer activity through a variety of mechanisms. The
macro-molecules themselves may have anticancer activities, or, more typically, inert …
macro-molecules themselves may have anticancer activities, or, more typically, inert …