Loss of auditory and vestibular hair cells is a common cause of hearing loss and balance
disorders. A variety of strategies have been proposed to restore function to damaged inner …

Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …

Objectives/Hypothesis Determine the optimal design characteristics of an adenoviral (Ad)
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …

Therapies for the protection and regeneration of auditory hair cells are of great interest given
the significant monetary and lifestyle impact of hearing loss. The past decade has seen …

Introduction: The sensory epithelium of the cochlea is a complex structure containing hair
cells, supporting cells and auditory nerve endings, all of which degenerate after hearing loss …

The hallmark of mechanosensory hair cells is the stereocilia, where mechanical stimuli are
converted into electrical signals. These delicate stereocilia are susceptible to acoustic …

Despite the significant impact of hearing and balance disorders on the general population
there are currently no dedicated pharmaceuticals that target the inner ear. Advances in …

Background: Loss of peripheral vestibular function is associated with disease processes
such as vestibular neuronitis, aminoglycoside ototoxicity, and aging. Loss of vestibular hair …

In the mammalian auditory system, sensory cell loss resulting from aging, ototoxic drugs,
infections, overstimulation and other causes is irreversible and leads to permanent …

Abstract Objectives/Hypothesis: To evaluate the ability of the Ad28. gfap. atoh1 to promote
hair cell regeneration and hearing recovery in cochlea injured with kanamycin and …