Proliferation of smooth muscle cells (SMC), enhancement of polyamine biosynthesis and
increase in polyamine level in response to deendothelialization in the rat aorta were …

Objective: The aim was to investigate the involvement of polyamines in the development of
cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension. Methods …

Inhibition of cardiac ornithine decarboxylase (ODC) by α-difluoromethylornithine (DFMO) did
not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced …

In the rat heart, there is a remarkable remodeling due to catecholamines. As to the functional
effects, norepinephrine (NE) induced a marked positive chronotropic effect and an elevation …

Among the mechanisms that have been proposed to be involved in the stimulation of protein
synthesis associated with the development of cardiac hypertrophy [I, 6, 7, 8, 9, 11, 12, 14 …

Ornithine decarboxylase is a rate-limiting step in the formation of the polyamines
(putrescine, spermidine, and spermine). Ornithine decarboxylase activity (ODC) is increased …

The present study examined whether the previously reported hypertrophy and increased
expression of insulin-like growth factor I (IGF-I) mRNA in the volume-overloaded right …

The objective of this study was to examine the effect of indapamide on cAMP generation in
cardiomyocytes. Viable ventricular myocytes were isolated from adult rat hearts which …

Abstract Sprague Dawley male rats (200–220 g) were subjected to a long-term treatment
with low doses of catecholamines in an attempt to assess the effect of the adrenergic …

Studies of stress-induced cardiac hypertrophy suggest that myocardial mass is regulated by
the circulating level of epinephrine. The trophic effect is mediated by cardiac beta …