Radiation as immunomodulator: implications for dendritic cell-based immunotherapy
RE Roses, J Datta, BJ Czerniecki - Radiation research, 2014 - meridian.allenpress.com
The last decade has witnessed significant progress in the field of cancer immunotherapy.
This has, in part, been driven by a growing recognition that elements of the innate immune …
This has, in part, been driven by a growing recognition that elements of the innate immune …
Lymphatic vessels in tumor dissemination versus immunotherapy
K Vaahtomeri, K Alitalo - Cancer research, 2020 - AACR
During the growth of various cancers, primary tumors can escape antitumor immune
responses of their host and eventually disseminate into distant organs. Peritumoral …
responses of their host and eventually disseminate into distant organs. Peritumoral …
Norm-and hypo-fractionated radiotherapy is capable of activating human dendritic cells
L Kulzer, Y Rubner, L Deloch, A Allgäuer… - Journal of …, 2014 - Taylor & Francis
Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical
treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor …
treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor …
Drug-and cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells
A Galetto, S Buttiglieri, S Forno, F Moro… - Anti-cancer …, 2003 - journals.lww.com
The way a tumor cell dies is believed to influence both its engulfment by dendritic cells (DC)
and access of the relevant antigen (s) to the cross-presentation pathway. Here we have …
and access of the relevant antigen (s) to the cross-presentation pathway. Here we have …
[HTML][HTML] Role of T lymphocytes in tumor response to radiotherapy
S Demaria, SC Formenti - Frontiers in oncology, 2012 - frontiersin.org
Over thirty years ago, Helen Stone and colleagues compared the effects of local tumor
irradiation in immunocompetent and T cell deficient mice, providing the first evidence that …
irradiation in immunocompetent and T cell deficient mice, providing the first evidence that …
[HTML][HTML] Immunotherapy goes local: the central role of lymph nodes in driving tumor infiltration and efficacy
KM Van Pul, MF Fransen, R Van de Ven… - Frontiers in …, 2021 - frontiersin.org
Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but
its impact is limited by primary or secondary resistance. ICB resistance has been related to a …
its impact is limited by primary or secondary resistance. ICB resistance has been related to a …
Lymph-directed immunotherapy–Harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer
OM Feeney, G Gracia, DHS Brundel… - Advanced Drug Delivery …, 2020 - Elsevier
The advent of immunotherapy has revolutionised the treatment of some cancers. Harnessing
the immune system to improve tumour cell killing is now standard clinical practice and …
the immune system to improve tumour cell killing is now standard clinical practice and …
Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions
A Filatenkov, J Baker, AMS Mueller, J Kenkel… - Clinical Cancer …, 2015 - AACR
Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …
desirable complete remissions of murine colon tumors treated with single radiation dose of …
Immunobiology of radiotherapy: new paradigms
Mansoor M. Ahmed, a Chandan Guha, b James W. Hodgec and Elizabeth Jaffeed a
Radiation Research Program, National Cancer Institute/National Institutes of Health …
Radiation Research Program, National Cancer Institute/National Institutes of Health …
Immune responses in the draining lymph nodes against cancer: implications for immunotherapy
S Shu, AJ Cochran, RR Huang, DL Morton… - Cancer and Metastasis …, 2006 - Springer
Regional lymph nodes are the first site for melanoma metastases. The sentinel node (SN),
on the direct lymphatic drainage pathway, which usually harbors first metastases …
on the direct lymphatic drainage pathway, which usually harbors first metastases …