The last decade has witnessed significant progress in the field of cancer immunotherapy.
This has, in part, been driven by a growing recognition that elements of the innate immune …

During the growth of various cancers, primary tumors can escape antitumor immune
responses of their host and eventually disseminate into distant organs. Peritumoral …

Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical
treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor …

The way a tumor cell dies is believed to influence both its engulfment by dendritic cells (DC)
and access of the relevant antigen (s) to the cross-presentation pathway. Here we have …

Over thirty years ago, Helen Stone and colleagues compared the effects of local tumor
irradiation in immunocompetent and T cell deficient mice, providing the first evidence that …

Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but
its impact is limited by primary or secondary resistance. ICB resistance has been related to a …

The advent of immunotherapy has revolutionised the treatment of some cancers. Harnessing
the immune system to improve tumour cell killing is now standard clinical practice and …

Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …

Mansoor M. Ahmed, a Chandan Guha, b James W. Hodgec and Elizabeth Jaffeed a
Radiation Research Program, National Cancer Institute/National Institutes of Health …

Regional lymph nodes are the first site for melanoma metastases. The sentinel node (SN),
on the direct lymphatic drainage pathway, which usually harbors first metastases …