Combining radiotherapy and immunotherapy: a revived partnership
S Demaria, N Bhardwaj, WH McBride… - International Journal of …, 2005 - Elsevier
Ionizing radiation therapy (RT) is an important local modality for the treatment of cancer. The
current rationale for its use is based largely on the ability of RT to kill the cancer cells by a …
current rationale for its use is based largely on the ability of RT to kill the cancer cells by a …
Trial watch: anticancer radioimmunotherapy
E Vacchelli, I Vitale, E Tartour, A Eggermont… - …, 2013 - Taylor & Francis
Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …
cancer throughout the last century, with a varying degree of success. For a long time, the …
[PDF][PDF] Radiation-induced immune responses: mechanisms and therapeutic perspectives
H Jeong, S Bok, BJ Hong, HS Choi… - Blood research, 2016 - synapse.koreamed.org
Recent advancement in the radiotherapy technology has allowed conformal delivery of high
doses of ionizing radiation precisely to the tumors while sparing large volume of the normal …
doses of ionizing radiation precisely to the tumors while sparing large volume of the normal …
Immune modulation by ionizing radiation and its implications for cancer immunotherapy
EJ Friedman - Current pharmaceutical design, 2002 - ingentaconnect.com
Ionizing radiation exhibits immunomodulatory properties, which could portend a future
collaboration of cancer immunotherapy with radiation therapy. The “danger” model of …
collaboration of cancer immunotherapy with radiation therapy. The “danger” model of …
Immunomodulatory roles of lymphatic vessels in cancer progression
MA Swartz - Cancer immunology research, 2014 - AACR
Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in
many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the …
many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the …
Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon γ secretion is associated with in vivo therapeutic efficacy of activated tumor-draining …
A Aruga, S Shu, AE Chang - Cancer Immunology, Immunotherapy, 1995 - Springer
In this study, cytokine release by tumor-draining lymph node cells sensitized in vitro (IVS-
TDLN) was examined and correlated with therapeutic efficacy in adoptive immunotherapy …
TDLN) was examined and correlated with therapeutic efficacy in adoptive immunotherapy …
Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
Transgenic mice expressing the oncogene SV40 T antigen (Tag) in the insulin-producing β
cells of the pancreas develop islet cell carcinomas. Expression of the oncogene beginning …
cells of the pancreas develop islet cell carcinomas. Expression of the oncogene beginning …
Immuno-oncology: Allying forces of radio-and immuno-therapy to enhance cancer cell killing
J Bernier - Critical reviews in oncology/hematology, 2016 - Elsevier
Besides the local effects of ionizing radiation at the cellular and molecular levels in tumor
tissues, the interactions of radiotherapy with the host's immune system are nowadays at the …
tissues, the interactions of radiotherapy with the host's immune system are nowadays at the …
[HTML][HTML] Evaluation of in vivo labelled dendritic cell migration in cancer patients
R Ridolfi, A Riccobon, R Galassi, G Giorgetti… - Journal of Translational …, 2004 - Springer
Abstract Background Dendritic Cell (DC) vaccination is a very promising therapeutic strategy
in cancer patients. The immunizing ability of DC is critically influenced by their migration …
in cancer patients. The immunizing ability of DC is critically influenced by their migration …
Positive lymph nodes do not metastasize
J Engel, RT Emeny, D Hölzel - Cancer and Metastasis Reviews, 2012 - Springer
Our understanding of the role of lymph nodes (LN) in the metastasization process (MET) is
marginal. Positive LNs (pLN) are the most important prognostic factor and lymph node …
marginal. Positive LNs (pLN) are the most important prognostic factor and lymph node …