Ionizing radiation therapy (RT) is an important local modality for the treatment of cancer. The
current rationale for its use is based largely on the ability of RT to kill the cancer cells by a …

Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …

Recent advancement in the radiotherapy technology has allowed conformal delivery of high
doses of ionizing radiation precisely to the tumors while sparing large volume of the normal …

Ionizing radiation exhibits immunomodulatory properties, which could portend a future
collaboration of cancer immunotherapy with radiation therapy. The “danger” model of …

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in
many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the …

In this study, cytokine release by tumor-draining lymph node cells sensitized in vitro (IVS-
TDLN) was examined and correlated with therapeutic efficacy in adoptive immunotherapy …

Transgenic mice expressing the oncogene SV40 T antigen (Tag) in the insulin-producing β
cells of the pancreas develop islet cell carcinomas. Expression of the oncogene beginning …

Besides the local effects of ionizing radiation at the cellular and molecular levels in tumor
tissues, the interactions of radiotherapy with the host's immune system are nowadays at the …

Abstract Background Dendritic Cell (DC) vaccination is a very promising therapeutic strategy
in cancer patients. The immunizing ability of DC is critically influenced by their migration …

Our understanding of the role of lymph nodes (LN) in the metastasization process (MET) is
marginal. Positive LNs (pLN) are the most important prognostic factor and lymph node …