Background Depression is a common mental disorder characterized by persistent sadness
and lack of interest or pleasure in previously rewarding or enjoyable activities …

Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic
metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been …

Rosmarinic acid (RA), a primary constituent of a Chinese herbal medicine, has been shown
to have some therapeutic effects in an animal model of depression, but its underlying …

Paecilomyces hepiali contains identical chemical constituents to Cordyceps sinensis, and it
presents antidepressant‑like activity via regulating noradrenergic and dopaminergic …

Treatment with the antihypertensive agent reserpine depletes monoamine levels, resulting
in depression. In the present study, we evaluated the antidepressant effects of …

Neuroinflammation is considered as one of the common pathogeneses of depression.
Huanglian‐Jie‐Du‐Tang (HJDT) is a traditional Chinese herbal formula. The present study …

Quercetin, a naturally occurring flavonoid, has been reported to exert antidepressant effects,
however, the underlying mechanisms are still uncertain. Recent studies have demonstrated …

Rosmarinic acid (RA), a natural phenolic acid compound with a variety of bioactive
properties. However, the antidepressant activity and mechanism of RA remain unclear. The …

A growing number of studies is focusing on the pharmacology and feasibility of bioactive
compounds as a novel valuable approach to target a variety of human diseases related to …

The present study was performed to investigate the antidepressant effect of echinacoside
(ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and …