Development of functional tissues often requires spatially controlled growth of cells over 2D
surfaces or 3D substrates to maintain their distinct cellular functions; particularly it is …

Surface patterning becomes an important tool in biomedical research and applications, as it
enables systematic investigation of cell-biomaterial interaction as well as rapid, high …

Cellular behavior can be influenced by the chemical and physical surface characteristics of
biomedical substrates. To understand the relationships between various topographical …

Topographical patterning has recently attracted lots of attention in regulating cell fate,
understanding the mechanism of cell–microenvironment interactions, and solving the great …

Patterned scaffold surfaces provide a platform for highly defined cellular interactions, and
have recently taken precedence in tissue engineering. Despite advances in patterning …

Cell–material interactions constitute a key fundamental topic in biomaterials study. Various
cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials …

In the area of biomaterials, there has been recent activity in the use of micro-and
nanofabrication technology to alter material surfaces for influencing the attachment and …

Stem cells possess unique abilities as they can renew themselves for extended periods of
time and have the capacity to differentiate into a variety of lineages. They hold promise for …

Methods for the creation of specially designed surfaces for use in the preparation of tailor-
made tissue constructs with the ultimate aim of tissue engineering are reviewed here …

54-2 Tissue Engineering cell–soluble factor interactions. In this chapter, we discuss some
aspects of surface patterning of biomaterials, both chemical and topographical, suitable for …