While a number of factors may initiate structural alterations within the cardiovascular system
in response to hypertension, there are obligate cellular signaling mechanisms, such as the …

Biochemical mechanisms which control cardiac and vascular response to hypertension are
still unclear. Modifications of polyamines (putrescine, spermine, spermidine) may play a role …

Cardiac muscle hypertrophy is one of the most important compensatory responses of the
heart to multiple stresses that may be placed on it. If the stress is not relieved, sustained …

Objective: The aim was to investigate the involvement of polyamines in the development of
cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension. Methods …

Endogenous polyamines play a key role in mediating cellular growth and differentiation.
Hypertension is associated with structural modifications of the circulatory system, a process …

This study was performed to assess the potential role of polyamines in the alterations in
vascular structure and function in spontaneously hypertensive rats (SHR). The effects of …

抄録 It is well known that isoproterenol (ISO) a nonselective β adrenoceptor agonist induces
cardiac hypertrophy. It can be assumed that, in addition to its direct cardiac effect, ISO has a …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

To evaluate the role of polyamine biosynthesis in myocardial growth, the activity of ornithine
decarboxylase (ODC) and the levels of the polyamines, spermidine, spermine, and …

Treatment with thyroxine for 7 days to produce myocardial hypertrophy led to an increase in
the content of putrescine, spermidine, and spermine in the rat heart. The content of …