A key issue for cancer biology and therapy is whether the relentless growth of a tumor is
driven by a substantial proportion of its cells or exclusively by a rare subpopulation …

The cancer stem cell hypothesis postulates that tumor growth is driven by a rare
subpopulation of tumor cells. Much of the supporting evidence for this intriguing idea is …

The cancer stem cell hypothesis posits that tumor growth is driven by a rare subpopulation of
cells, designated cancer stem cells (CSC). Studies supporting this theory are based in large …

Although monoclonal in origin, most tumors appear to contain a heterogeneous population
of cancer cells. This observation is traditionally explained by postulating variations in tumor …

The theory of cancer stem cells states that a subset of cancer cells within a tumor has the
ability to self-renew and differentiate. Only those cells within a tumor that have these two …

Building on studies of leukemia, a number of recent articles have reported data suggesting
that cancer stem cells could be isolated from solid human cancers. Some of these reports …

A fundamental problem in cancer research is identification of the cells within a tumor that
sustain the growth of the neoplastic clone. The concept that only a subpopulation of rare …

Although the concept that cancers arise from “stem cells” or “germ cells” was first proposed
about 150 years ago, it is only recently that advances in stem cell biology have given new …

Over the past two decades, major advances in our understanding of cancer have translated
into only modest increments in survival for the majority of cancer patients. Recent data …

There is growing realization that many–if not all–cancer-cell populations contain a
subpopulation of self-renewing stem cells known as cancer stem cells (CSCs). Unlike …