One of the major challenges in treatment of auditory disorders is that many therapeutic
compounds are toxic when delivered systemically. Local intracochlear delivery methods are …

The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in
drug-based treatment of auditory disorders. This also makes pharmacokinetic …

Introduction: Diseases of the inner ear include those of the auditory and vestibular systems,
and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding …

The inner ear represents one of the most technologically challenging targets for local drug
delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural …

Introduction: Advances in molecular biology and in the basic understanding of the
mechanisms associated with sensorineural hearing loss and other diseases of the inner ear …

There is a growing prevalence of hearing loss across the globe, with over 360 million
patients worldwide suffering from this condition. Factors such an increasingly aging …

Background: Direct delivery of drugs and other agents into the inner ear will be important for
many emerging therapies, including the treatment of degenerative disorders and guiding …

Advances in protective and restorative biotherapies have created new opportunities to use
site-directed, programmable drug delivery systems to treat auditory and vestibular disorders …

Reciprocating microfluidic drug delivery, as compared to steady or pulsed infusion, has
unique features which may be advantageous in many therapeutic applications. We have …

Due to the very small size of the mouse inner ear, 600 nL volume, developing effective,
controlled infusion systems is quite challenging. Key technologies have been created to …