Arterioles exposed to norepinephrine (NE) for 4 h exhibit incomplete relaxation on removal
of the agonist. We hypothesized that this is due to a mechanoadaptation process associated …

Structural adaptation in arterioles is part of normal vascular physiology but is also seen in
disease states such as hypertension. Smooth muscle cell (SMC) activation has been shown …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall and
normally adopt a quiescent, contractile phenotype to regulate vascular tone. In the arterial …

Experiments were performed to determine whether remodeling of the actin cytoskeleton
contributes to arteriolar constriction. Mouse tail arterioles were mounted on cannulae in a …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

The differentiated vascular smooth muscle cell (SMC) is a highly specialized cell that
expresses a unique repertoire of contractile proteins, ion channels, membrane receptors …

Contraction of small artery (diameters typically less than 250μm) vascular smooth muscle
cells (VSMCs) plays a critical role in local control of blood flow and arterial pressure through …

The physiologic role of smooth muscle structure in defining arterial function is poorly
understood. We aimed to elucidate the relationship between vascular smooth muscle …

During vascular remodeling in adult organisms, new capillary growth is often coupled with
the adaptation of arterioles and venules, a process that requires the recruitment and …

Vascular smooth muscle cells (vSMCs) can switch between a contractile (differentiated) and
a synthetic (dedifferentiated) phenotype. Synthetic, proliferative vSMCs are observed during …