Current hurdles to the translation of nanomedicines from bench to the clinic

S Đorđević, MM Gonzalez, I Conejos-Sánchez… - Drug delivery and …, 2022 - Springer
The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …

Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities

V Agrahari, V Agrahari - Drug Discovery Today, 2018 - Elsevier
Highlights•Clinical translation and commercialization challenges of nanomedicine products.•
Manufacturing or scale-up, characterization, safety, stability and efficacy …

Characterization of nanomedicines: A reflection on a field under construction needed for clinical translation success

JB Coty, C Vauthier - Journal of controlled release, 2018 - Elsevier
The nanotechnology revolution offers many expectations for the improvement of medicine
treatments. At present, nanomedicine (NM) development is hampered by methodological …

Challenges in nanomedicine clinical translation

JM Metselaar, T Lammers - Drug delivery and translational research, 2020 - Springer
New nanomedicine formulations and novel applications of nanomedicinal drugs are
reported on an almost daily basis. While academic progress and societal promise continue …

Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Translational formulation of nanoparticle therapeutics from laboratory discovery to clinical scale

J Feng, CE Markwalter, C Tian, M Armstrong… - Journal of translational …, 2019 - Springer
Background “Nanomedicine” is the application of purposely designed nano-scale materials
for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved …

Nanomedicines: from bench to bedside and beyond

H Havel, G Finch, P Strode, M Wolfgang, S Zale… - The AAPS journal, 2016 - Springer
Advancing nanomedicines from concept to clinic requires integration of new science with
traditional pharmaceutical development. The medical and commercial success of …

Evolution and clinical translation of drug delivery nanomaterials

S Hassan, G Prakash, AB Ozturk, S Saghazadeh… - Nano today, 2017 - Elsevier
With the advent of technology, the role of nanomaterials in medicine has grown
exponentially in the last few decades. The main advantage of such materials has been …

[HTML][HTML] Delivering the power of nanomedicine to patients today

M Germain, F Caputo, S Metcalfe, G Tosi… - Journal of Controlled …, 2020 - Elsevier
The situation of the COVID-19 pandemic reminds us that we permanently need high-value
flexible solutions to urgent clinical needs including simplified diagnostic technologies …

Nanomedicine (s) under the microscope

R Duncan, R Gaspar - Molecular pharmaceutics, 2011 - ACS Publications
Depending on the context, nanotechnologies developed as nanomedicines (nanosized
therapeutics and imaging agents) are presented as either a remarkable technological …