The aggressive proliferation of tumor cells often requires increased glucose uptake and
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in
tumors holds great promise for the reversal of the immunosuppressive tumor …

Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …

Metabolic reprogramming allows tumor cells to prefer aerobic glycolysis as the main energy
source, resulting in the massive accumulation of lactate in the tumor microenvironment …

An effective systemic mechanism regulates tumor development and progression; thus, a
rational design in a one‐stone‐two‐birds strategy is meant for cancer treatment. Herein, a …

The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune
cells in the TME. Here, we report inorganic nanozymes (ie, SnSe NSs) that mimic the …

Acidosis and hypoxia of tumor remain a great challenge for cancer therapy. Herein, we
developed Hb-LOX-DOX-ZIF8@ platelet membrane nanoparticles (HLDZ@ PM NPs) to …

Nanozyme with the “dual identity” of enzymes and nanomaterials is an emerging strategy to
mimic natural enzymes in bio-nanotechnology. However, how to improve the nanozyme …

Inspired by the particularity of tumor microenvironments, including acidity and sensibility to
reactive oxygen species (ROS), advanced and smart responsive nanomaterials have …

Enzymes play pivotal roles in regulating and maintaining the normal functions of all living
systems, and some of them are extensively employed for diagnosis and treatment of diverse …