CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology
Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …
processes and whose dysfunction may contribute to several different diseases, such as …
Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives
S Comai, M Lopez-Canul, D De Gregorio… - Pharmacological …, 2019 - Elsevier
Melatonin (MLT), a neuromodulator mainly acting through two G-protein coupled receptors
MT 1 and MT 2, regulates many brain functions, including circadian rhythms, mood, pain and …
MT 1 and MT 2, regulates many brain functions, including circadian rhythms, mood, pain and …
[HTML][HTML] Differential function of melatonin MT1 and MT2 receptors in REM and NREM sleep
The pathophysiological function of the G-protein coupled melatonin MT 1 and MT 2
receptors has not yet been well-clarified. Recent advancements using selective MT 1/MT 2 …
receptors has not yet been well-clarified. Recent advancements using selective MT 1/MT 2 …
The pattern of melatonin receptor expression in the brain may influence antidepressant treatment
E Hirsch-Rodriguez, M Imbesi, R Manev, T Uz… - Medical hypotheses, 2007 - Elsevier
The pineal hormone melatonin produces most of its biological effects via G protein-coupled
receptors MT1 and MT2. In mammals, these receptors are expressed in various tissues and …
receptors MT1 and MT2. In mammals, these receptors are expressed in various tissues and …
Melatonergic receptors (Mt1/Mt2) as a potential additional target of novel drugs for depression
A complex pathogenesis involving several physiological systems is theorized to underline
the development of depressive disorders. Depression is accompanied by circadian …
the development of depressive disorders. Depression is accompanied by circadian …
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective
J Liu, SJ Clough, AJ Hutchinson… - Annual review of …, 2016 - annualreviews.org
Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …
gland and locally in the retina following a circadian rhythm, with low levels during the day …
Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease
Melatonin, the neuro‐hormone synthesized during the night, has recently seen an
unexpected extension of its functional implications toward type 2 diabetes development …
unexpected extension of its functional implications toward type 2 diabetes development …
Recent advances in the development of melatonin MT1 and MT2 receptor agonists
Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam
Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein …
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein …
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
Melatonin activates two brain G-protein coupled receptors, MT1 and MT2, whose differential
roles in the sleep–wake cycle remain to be defined. The novel MT2 receptor partial agonist …
roles in the sleep–wake cycle remain to be defined. The novel MT2 receptor partial agonist …