Human cells acquire somatic mutations throughout life, some of which can drive clonal
expansion. Such expansions are frequent in the hematopoietic system of healthy individuals …

Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and
their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for …

Anemia is a major and currently poorly understood clinical manifestation of hematopoietic
aging. Upon aging, hematopoietic clones harboring acquired leukemia-associated …

Clonal hematopoiesis (CH) in the elderly is associated with increased risk for a variety of
diseases, including myeloid malignancies. However, as not all CH subjects develop myeloid …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Somatic mutations acquired in haematopoietic stem cells can drive clonal expansions, a
phenomenon called clonal haematopoiesis (CH). CH has been associated with higher risk …

The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

Human aging is marked by the emergence of a tapestry of clonal expansions in dividing
tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk …