The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper
understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we …

The role of mitochondria in Drosophila programmed cell death remains unclear, although
certain gene products that regulate cell death seem to be evolutionarily conserved. We find …

Mitochondria play a critical role in neuronal function and neurodegenerative disorders,
including Alzheimer's, Parkinson's and Huntington diseases and amyotrophic lateral …

Mitochondrial quality control is essential in highly structured cells such as neurons and
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …

The effects of aging on the brain are widespread and can have dramatic implications on the
overall health of an organism. Mitochondrial dysfunction is a hallmark of brain aging, but the …

Mitochondrial morphology is dynamically controlled by a balance between fusion and
fission. The physiological importance of mitochondrial fission in vertebrates is less clearly …

Most cell death stimuli trigger the mitochondrial release of cytochrome c and other cofactors
that induce caspase activation and ensuing apoptosis. Apoptosis is also associated with …

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted
balance between the process of mitochondrial fusion and fission is required to maintain …

Ageing of biological systems is accompanied by alterations in mitochondrial morphology,
including a transformation from networks and filaments to punctuate units. The significance …

Current research has demonstrated that mitochondrial morphology, distribution, and function
are maintained by the balanced regulation of mitochondrial fission and fusion, and …