A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
Progress and challenges in genome-wide association studies in humans
P Donnelly - Nature, 2008 - nature.com
After more than a decade of hope and hype, researchers are finally making inroads into
understanding the genetic basis of many common human diseases. The use of genome …
understanding the genetic basis of many common human diseases. The use of genome …
[HTML][HTML] The genotype-tissue expression (GTEx) project
J Lonsdale, J Thomas, M Salvatore, R Phillips, E Lo… - Nature …, 2013 - nature.com
Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
Phenome connections
M Oti, MA Huynen, HG Brunner - Trends in genetics, 2008 - cell.com
Human phenomics is about to come of age with studies that systematically assess the
overlap and relationships among all human genetic diseases. A recent study by Andrey …
overlap and relationships among all human genetic diseases. A recent study by Andrey …
Progress and promise in understanding the genetic basis of common diseases
AL Price, CCA Spencer… - Proceedings of the …, 2015 - royalsocietypublishing.org
Susceptibility to common human diseases is influenced by both genetic and environmental
factors. The explosive growth of genetic data, and the knowledge that it is generating, are …
factors. The explosive growth of genetic data, and the knowledge that it is generating, are …
A plethora of pleiotropy across complex traits
PM Visscher, J Yang - Nature genetics, 2016 - nature.com
A new analysis has identified hundreds of loci that are associated with multiple traits or
diseases by comparing genome-wide association study (GWAS) data for 42 complex traits …
diseases by comparing genome-wide association study (GWAS) data for 42 complex traits …
Genome-wide association studies for common diseases and complex traits
JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
Predicting genetic predisposition in humans: the promise of whole-genome markers
Although genome-wide association studies have identified markers that are associated with
various human traits and diseases, our ability to predict such phenotypes remains limited. A …
various human traits and diseases, our ability to predict such phenotypes remains limited. A …
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information
Background The genetic contributions to human common disorders and mouse genetic
models of disease are complex and often overlapping. In common human diseases, unlike …
models of disease are complex and often overlapping. In common human diseases, unlike …
Deconstructing the sources of genotype-phenotype associations in humans
Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …
tremendous pace in recent decades. Most human traits have been shown to be affected by a …