The fate of adult stem cells can be influenced by physical cues, including nanotopography.
However, the response of human embryonic stem cells (hESCs) to dimensionally well …

Adherent cells respond to a wide range of substrate cues, including chemistry, topography,
hydrophobicity, and surface energy. The cell‐substrate interface is therefore an important …

Human embryonic stem cells (hESCs) have great potentials for future cell-based
therapeutics. However, their mechanosensitivity to biophysical signals from the cellular …

Inefficient neural differentiation of human induced pluripotent stem cells (hiPSCs) motivates
recent investigation of the influence of biophysical characteristics of cellular …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

The maintenance of stem cell pluripotency or stemness is crucial to embryonic development
and differentiation. The mechanical or physical microenvironment of stem cells, which …

Recently emerging evidence has indicated surface nanotopography as an important
physical parameter in the stem cell niche for regulating cell fate and behaviors for various …

Stem cell differentiation can be regulated by biophysical cues such as nanotopography. It
involves sensing and integration of these biophysical cues into their transcriptome with a …

Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo
microenvironment. In recent years, manipulating the micro-and nano-scale topography of …

Pluripotent human embryonic stem cells (hESCs) have the capability of differentiating into
different lineages based on specific environmental cues. We had previously shown that …