It is well established that topographical features modulate cell behaviour, including cell
morphology, proliferation and differentiation. To define the effects of topography on human …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …

Pluripotent stem cells have the potential to develop into all cell types of the adult body.
Besides chemical and mechanical cues, topographical effect of surfaces could also …

Surface nanotopographies are an important way of mimicking the stem cell niche on
biomaterial surfaces. Previous studies have focused on the differentiation of stem cells into a …

To understand how cells respond to the nanoscale extracellular environment in vivo, cells
from various sources have been cultured on nanoscale patterns fabricated using bottom-up …

OCT4 is a master transcriptional regulator, which mediates pluripotency in ESCs through
inhibition of tissue-specific and promotion of stem cell-specific genes. Suppression of OCT4 …

Stem cells are unspecialized cells that can self renew indefinitely and differentiate into
several somatic cells given the correct environmental cues. In the stem cell niche, stem cell …

Regulating cell behavior using nanotopography has been widely implemented. To facilitate
cell adhesion, physical nanotopography is usually coated with adhesive proteins such as …

The topography of a biomaterial regulates cellular interactions and determine stem cell fate.
A complete understanding of how topographical properties affect cell behavior will allow the …