[HTML][HTML] Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells

A Reimer, A Vasilevich, F Hulshof, P Viswanathan… - Scientific reports, 2016 - nature.com
It is well established that topographical features modulate cell behaviour, including cell
morphology, proliferation and differentiation. To define the effects of topography on human …

[PDF][PDF] An Oct4-centered protein interaction network in embryonic stem cells

DLC van den Berg, T Snoek, NP Mullin, A Yates… - Cell stem cell, 2010 - cell.com
Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

Engineering nanoscale stem cell niche: direct stem cell behavior at cell–matrix interface

Y Zhang, A Gordon, W Qian… - Advanced healthcare …, 2015 - Wiley Online Library
Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …

Topographic effect on human induced pluripotent stem cells differentiation towards neuronal lineage

F Pan, M Zhang, G Wu, Y Lai, B Greber, HR Schöler… - Biomaterials, 2013 - Elsevier
Pluripotent stem cells have the potential to develop into all cell types of the adult body.
Besides chemical and mechanical cues, topographical effect of surfaces could also …

Heterogeneity of mesenchymal and pluripotent stem cell populations grown on nanogrooves and nanopillars

PY Wang, S Ding, H Sumer, RCB Wong… - Journal of materials …, 2017 - pubs.rsc.org
Surface nanotopographies are an important way of mimicking the stem cell niche on
biomaterial surfaces. Previous studies have focused on the differentiation of stem cells into a …

Osteoblast and stem cell response to nanoscale topographies: a review

NI Aminuddin, R Ahmad, SA Akbar… - … and Technology of …, 2016 - Taylor & Francis
To understand how cells respond to the nanoscale extracellular environment in vivo, cells
from various sources have been cultured on nanoscale patterns fabricated using bottom-up …

Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells

SJ Greco, K Liu, P Rameshwar - Stem cells, 2007 - academic.oup.com
OCT4 is a master transcriptional regulator, which mediates pluripotency in ESCs through
inhibition of tissue-specific and promotion of stem cell-specific genes. Suppression of OCT4 …

[HTML][HTML] Effects of nanotopography on stem cell phenotypes

R Ravichandran, S Liao, CCH Ng, CK Chan… - World journal of stem …, 2009 - ncbi.nlm.nih.gov
Stem cells are unspecialized cells that can self renew indefinitely and differentiate into
several somatic cells given the correct environmental cues. In the stem cell niche, stem cell …

Dissecting physical and biochemical effects in nanotopographical regulation of cell behavior

K Wang, K Man, J Liu, B Meckes, Y Yang - ACS nano, 2023 - ACS Publications
Regulating cell behavior using nanotopography has been widely implemented. To facilitate
cell adhesion, physical nanotopography is usually coated with adhesive proteins such as …

[HTML][HTML] Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis

P Newman, JL Galenano-Niño, P Graney, JM Razal… - Scientific Reports, 2016 - nature.com
The topography of a biomaterial regulates cellular interactions and determine stem cell fate.
A complete understanding of how topographical properties affect cell behavior will allow the …