Surface topography has been reported to play a key role in modulating cell behaviors, yet
the mechanism through which it modulates these behaviors is not fully understood …

Stem cells are known for their potential to repair damaged tissues. The adhesion, growth
and differentiation of stem cells are likely controlled by the surrounding microenvironment …

Cells in their native microenvironment interact with three-dimensional (3D) nanofeatures.
Despite many reports on the effects of substrate nanotopography on cells, the independent …

Geometry and angles play crucial roles in cellular processes; however, its mechanisms of
regulation remain unclear. In this study, a series of three dimensional (3D)‐printed …

Mesenchymal stem cells (MSCs) are known to be ideal candidates for clinical applications
where not only regenerative potential but also immunomodulation ability are fundamental. In …

Human pluripotent cells such as human embryonic stem cells (hESC) are a great potential
source of cells for cell-based therapies; however, directing their differentiation into the …

Surface topography is able to influence cell phenotype in numerous ways and offers
opportunities to manipulate cells and tissues. In this work, we develop the Nano-TopoChip …

OCT4 is considered a main regulator of embryonic stem cell pluripotency and self renewal
capacity. It was shown that relevant OCT4 expression only occurs in cells of embryonic …

Amniogenesis—the development of amnion—is a critical developmental milestone for early
human embryogenesis and successful pregnancy,. However, human amniogenesis is …

Growing evidence suggests that physical microenvironments and mechanical stresses, in
addition to soluble factors, help direct mesenchymal-stem-cell fate. However, biological …