Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

To reproduce a complex and functional tissue, it is crucial to provide a biomimetic cellular
microenvironment that not only incorporates biochemical cues, but also physical features …

Although nanotopography has been shown to be a potent modulator of cell behavior, it is
unclear how the nanotopographical cue, through focal adhesions, affects the nucleus …

Engineered nanomaterials (ENMs) with different topographies provide effective nano–bio
interfaces for controlling the differentiation of stem cells. The interaction of stem cells with …

Background The octamer-binding transcription factor 4 (Oct4) was originally described as a
marker of embryonic stem cells. Recently, the role of Oct4 as a key regulator in pluripotency …

Cells sense cues in their surrounding microenvironment. These cues are converted into
intracellular signals and transduced to the nucleus in order for the cell to respond and adapt …

Skeletal muscle injury can lead to severe motor deficits that adversely affect movement and
quality of life. Current surgical treatments for skeletal muscle are hindered by the poor …

There is a rapidly growing body of literature on the effects of topography and critically,
nanotopography on cell adhesion, apoptosis and differentiation. Understanding the effects …

It is well known that biomaterials topography can influence the behavior of stem cells.
Nevertheless, the fundamentals and the impact of nanoscale topography are just emerging …

Mesenchymal stem/stromal cells respond to physical cues present in their microenvironment
such as substrate elasticity, geometry, or topography with respect to morphology …