Neuroinflammation: the devil is in the details

DJ DiSabato, N Quan, JP Godbout - Journal of neurochemistry, 2016 - Wiley Online Library
There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

The benefits of neuroinflammation for the repair of the injured central nervous system

HYF Yong, KS Rawji, S Ghorbani, M Xue… - Cellular & molecular …, 2019 - nature.com
Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …

Inflammation in neurological disorders: a help or a hindrance?

V Wee Yong - The Neuroscientist, 2010 - journals.sagepub.com
Inflammation of the central nervous system (CNS)(neuroinflammation) is now recognized to
be a feature of all neurological disorders. In multiple sclerosis, there is prominent infiltration …

[HTML][HTML] Does neuroinflammation fan the flame in neurodegenerative diseases?

TC Frank-Cannon, LT Alto, FE McAlpine… - Molecular …, 2009 - Springer
While peripheral immune access to the central nervous system (CNS) is restricted and tightly
controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety …

Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

NP Whitney, TM Eidem, H Peng… - Journal of …, 2009 - Wiley Online Library
Brain inflammation is a complex cellular and molecular response to stress, injury or infection
of the CNS in attempt to defend against insults, clear dead and damaged neurons and return …

[HTML][HTML] The role of microglia in modulating neuroinflammation after spinal cord injury

S Brockie, J Hong, MG Fehlings - International Journal of Molecular …, 2021 - mdpi.com
The pathobiology of traumatic and nontraumatic spinal cord injury (SCI), including
degenerative myelopathy, is influenced by neuroinflammation. The neuroinflammatory …

Central nervous system inflammation in disease related conditions: mechanistic prospects

A Fung, M Vizcaychipi, D Lloyd, Y Wan, D Ma - Brain research, 2012 - Elsevier
Inflammation is part of the innate immune response following insults to the body. This
inflammatory reaction can spread throughout the systemic circulation and also into the …

Is neuroinflammation in the injured spinal cord different than in the brain? Examining intrinsic differences between the brain and spinal cord

B Zhang, JC Gensel - Experimental neurology, 2014 - Elsevier
The field of neuroimmunology is rapidly advancing. There is a growing appreciation for
heterogeneity, both in inflammatory composition and region-specific inflammatory …

Macrophages and microglia in central nervous system injury: are they helpful or harmful?

M Schwartz - Journal of Cerebral Blood Flow & Metabolism, 2003 - journals.sagepub.com
Inflammation has been widely perceived as participating in the etiology of acute and chronic
neurodegenerative conditions. Accordingly, in the context of traumatic injuries or chronic …