Importance of the field: Melatonin is a major chronobiological regulator involved in circadian
phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is widely used as an over-the-counter therapy for the treatment of sleep disorders.
The discovery of novel potent melatonin agonists has led to the clinical development of a …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

In recent years, many physiological properties of melatonin have been described resulting in
much interest in the development of synthetic compounds possessing agonist or antagonist …

Melatonin, or N-acetyl 5-methoxytryptamine, a neurohormone produced in the pineal gland
during periods of darkness, plays a key role in the regulation of circadian and seasonal …

Melatonin the hormone secreted by the pineal gland has been effective in improving sleep
both in normal sleepers and insomniacs and has been used successfully in treating sleep …

Melatonin, a hormone secreted by the pineal gland, has been successfully employed to
improve sleep in both normal patients and insomniacs, and for the treatment of circadian …

The goal of the article is to provide a clearer understanding of how melatonin and its related
analogs interact with melatonin receptors with the hope of developing important tools and …

Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …