Metastasis to lymph nodes (LNs) is a common feature of disease progression in most solid
organ malignancies. Consequently, LN biopsy and lymphadenectomy are common clinical …

Metastasis to the regional lymph node is the most important prognostic indicator for the
outcomes of patients with sold cancer. In general, it is well recognized that cancer …

Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

Early in solid tumor development, antigens are presented in tumor-draining lymph nodes
(tdLNs), a process that is necessary to set up immune surveillance. Recent evidence …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

A new study by Lei et al.(2023) reveals a dynamic interplay between breast cancer cells and
the lymph node (LN) microenvironment that sets up local immune suppression. Interest in …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …

Our understanding of the role of lymph nodes (LN) in the metastasization process (MET) is
marginal. Positive LNs (pLN) are the most important prognostic factor and lymph node …

The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Lymph nodes (LNs) are principal orchestrators of the adaptive immune response, yet in the
context of malignancy, they are typically the first sites of metastasis. When tumors spread to …