Structural chromosomal aberrations as potential risk markers in incident cancer patients

S Vodenkova, Z Polivkova, L Musak… - …, 2015 - academic.oup.com
Epidemiological prospective studies have shown that increased chromosomal aberrations
(CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly …

Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls

P Vodicka, Z Polivkova, S Sytarova, H Demova… - …, 2010 - academic.oup.com
Background: The majority of human cancers arise from cells unable to maintain genomic
stability. Recent prospective studies indicated that enhanced chromosomal aberrations …

Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts

L Hagmar, U Strömberg, S Bonassi, IL Hansteen… - Cancer research, 2004 - AACR
The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood
lymphocytes is the first genotoxicity biomarker that has shown an association with cancer …

Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH)

L Hagmar, S Bonassi, U Strömberg, A Brøgger… - Cancer research, 1998 - AACR
Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), and micronuclei (MN)
in peripheral blood lymphocytes have for decades been used as cytogenetic biomarkers to …

Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

S Bonassi, A Abbondandolo, L Camurri… - Cancer genetics and …, 1995 - Elsevier
To investigate the existence of an association between the frequency of chromosome
aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried …

Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

S Bonassi, H Norppa, M Ceppi, U Strömberg… - …, 2008 - academic.oup.com
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has
been recently supported by the results of epidemiological studies that associated CA …

Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens

S Bonassi, L Hagmar, U Strömberg, AH Montagud… - Cancer Research, 2000 - AACR
An increased risk of cancer in healthy individuals with high levels of chromosomal
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …

Metabolic gene variants associated with chromosomal aberrations in healthy humans

K Hemminki, C Frank, A Försti, L Musak… - Genes …, 2015 - Wiley Online Library
Nonspecific chromosomal aberrations (CAs) are found in about 1% of lymphocytes drawn
from healthy individuals. They include chromosome‐type aberrations (CSAs), which are …

Chromosomal aberrations and SCEs as biomarkers of cancer risk

H Norppa, S Bonassi, IL Hansteen, L Hagmar… - Mutation Research …, 2006 - Elsevier
Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …

Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe

P Boffetta, O van der Hel, H Norppa… - American journal of …, 2007 - academic.oup.com
A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early
marker of cancer risk, but data on risk of specific cancers and types of chromosomal …