Connectivity mapping is a method used in the pharmaceutical industry to find connections
between small molecules, disease states, and genes. The concept can be applied to a …

Connectivity mapping is the process of establishing connections between different biological
states using gene-expression profiles or signatures. There are a number of applications but …

We previously demonstrated that the Connectivity Map (CMap)(Lamb et al., 2006) concept
can be successfully applied to a predictive toxicology paradigm to generate meaningful MoA …

Numbers of microarrays have been examined and several public and commercial
databases have been developed. However, it is not easy to compare in-house microarray …

Background: The field of toxicology has witnessed substantial advancements in recent
years, particularly with the adoption of new approach methodologies (NAMs) to understand …

The lack of adequate toxicity data for the vast majority of chemicals in the environment has
spurred the development of new approach methodologies (NAMs). This study aimed to …

Recently, we reported an in vitro toxicogenomics comparison approach to categorize
chemical substances according to similarities in their proposed toxicological modes of …

Screening new compounds for potential bioactivities against cellular targets is vital for drug
discovery and chemical safety. Transcriptomics offers an efficient approach for assessing …

Transcriptional profiling via microarrays holds great promise for toxicant classification and
hazard prediction. Unfortunately, the use of different microarray platforms, protocols, and …

High-throughput transcriptomics (HTTr) uses gene expression profiling to characterize the
biological activity of chemicals in in vitro cell-based test systems. As an extension of a …