The responses of AMP-activated protein kinase (AMPK) and Ornithine decarboxylase (ODC)
to isoproterenol have been examined in H9c2 cardiomyoblasts, AMPK represents the link …

The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase)
activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α …

Stimulation of cardiac AMP-activated protein kinase (AMPK) has been demonstrated in both
prohypertrophic and antihypertrophic settings, although the reasons for such discrepant …

These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

As AMP-activated protein kinase (AMPK) controls protein translation, an anti-hypertrophic
effect of AMPK has been suggested. However, there is no genetic evidence to confirm this …

AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis under
conditions of energy stress. Though heart is one of the most energy requiring organs and …

A necessary mediator of cardiac myocyte enlargement is protein synthesis, which is
controlled at the levels of both translation initiation and elongation. Eukaryotic elongation …