The peroxisomal very long chain fatty acid (VLCFA) transporter ABCD1 is central to fatty acid
catabolism and lipid biosynthesis. Its dysfunction underlies toxic cytosolic accumulation of …

Peroxisomes are essential organelles exerting key functions in fatty acid metabolism such
as the degradation of very long-chain fatty acids (VLCFAs). VLCFAs accumulate in X …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

ABCD1 and ABCD2 are two closely related ATP-binding cassette half-transporters predicted
to homodimerize and form peroxisomal importers for fatty acyl-CoAs. Available evidence has …

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane
proteins, and are present in almost all living organisms from eubacteria to mammals. They …

Dear Editor, ABCD1, a member of the subfamily D of ABC transporters, participates in the
transport of various fatty acid-CoA derivatives or very long-chain fatty acids (VLCFA) into the …

The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1,
ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids …

Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked
adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues …

ATP-binding cassette (ABC) transporters facilitate unidirectional translocation of chemically
diverse substances, ranging from peptides to lipids, across cell or organelle membranes. In …

X-linked adrenoleukodystrophy (X-ALD), the most common peroxisomal disorder, is caused
by mutations in the peroxisomal transporter ABCD1, resulting in the accumulation of very …