Background Iron deficiency (ID) results in ventricular hypertrophy, believed to involve
sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would …

Iron dysmetabolism affects a great proportion of heart failure patients, while chronic
hypertension is one of the most common risk factors for heart failure and death in …

Iron-overload cardiomyopathy is the most common cause of death in patients with
thalassemia major, yet the associated changes in cardiac function have not been quantified …

Periodic blood transfusion can lead to secondary iron overload in patients with hematologic
and oncologic diseases. Iron overload can result in iron deposition in heart tissue, which …

Background Sex‐related differences in cardiac function and iron metabolism exist in
humans and experimental animals. Male patients and preclinical animal models are more …

Background Chronic transfusion therapy causes a progressive iron overload that damages
many organs including the heart. Recent evidence suggests that L-type calcium channels …

Chronic heart failure (HF) is often accompanied by systemic iron deficiency (ID). However,
effects of ID on cardiac iron status and progression of HF are unknown. To investigate these …

Although iron excess is toxic to the vasculature and even that pulmonary hypertension has
been reported in this scenario, the role of iron overload per se remains to be clarified. This …

To evaluate the effects of the iron chelator deferoxamine on the functional and structural
manifestations of iron-induced cardiac dysfunction, we measured cardiac power, left …

New Findings What is the central question of this study? Head‐to‐head comparison of the
therapeutic efficacy among commercial iron chelators and a dual T‐(TTCC) and L‐type …