Highly active cardiomyocytes need iron for their metabolic activity. In physiological
conditions, iron turnover is a delicate process which is dependent on global iron supply and …

Excess cardiac iron levels are associated with cardiac damage and can result in increased
morbidity and mortality. Here, we hypothesize that elevations in tissue iron can activate …

Objectives: This study sought to determine the potential pathophysiological link between
anemia and disease severity, and adverse outcome in heart failure (HF). Background …

This study examined the effect of long-term administration of reserpine, an adrenergic
blocking agent, on cardiac hypertrophy in animals with severe iron deficiency anaemia. This …

Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts
symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied …

Iron is a key micronutrient for the human body and participates in biological processes, such
as oxygen transport, storage, and utilization. Iron homeostasis plays a crucial role in the …

We investigated the time course of electrocardiographic (ECG) changes in the Mongolian
gerbil model of iron overload and the effects of the iron chelator deferoxamine (DFO) on …

Iron is an element necessary for cells due to its capacity of transporting oxygen and
electrons. One of the important co-morbidities in heart failure is iron deficiency. Iron has …

Aims Iron deficiency is frequently observed in patients with acute coronary syndrome and
associates with poor prognosis after acute myocardial infarction (AMI). Anaemia is linked to …

Background Iron chelators are used to treat iron overload cardiomyopathy patients.
However, a direct comparison of the benefits of three common iron chelators (deferoxamine …