Due to the complex mechanisms of l-arginine activity, it is difficult to determine the clinical
significance of supplementation with this amino acid. The objective of this study was to …

Objective: To study the role of the L‐arginine/nitric oxide (NO) pathway during renal
ischaemia‐reperfusion in rats. Design: Randomised experimental study. Setting: Teaching …

In acute liver failure (ALF), the hyperdynamic circulation is believed to be the result of
overproduction of nitric oxide (NO) in the splanchnic circulation. However, it has been …

Nitric oxide (NO) protects the heart against some forms of reperfusion-associated
dysfunction (eg arrhythmias). Its role in protecting against other types of dysfunction is …

WHEN NITRIC OXIDE (NO) donors were first administered to isolated, normal
cardiomyocytes, a negative, cGMP-dependent inotropic effect was observed, whereas …

We previously found that myocardial ischemia/reperfusion (I/R) initiates expression of tumor
necrosis factor-α (TNF) leading to coronary endothelial dysfunction. However, it is not clear …

L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic
acute renal failure in rats. Background In ischemic acute renal failure (ARF), nitric oxide …

Nitric oxide (NO) is one of the important regulators of cardiac metabolism and function as
well as of tissue perfusion. Myocardial NO formation is increased during ischemia and …

Ischemia-reperfusion damages endothelium and impairs basal production of nitric oxide.
Basally released nitric oxide is cardioprotective by its inhibition of neutrophil activities. Loss …

Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology,
largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent …