Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the gal α1-3Galβ1-4GlcNAc-R (α-Gal) epitope

Z Hewitt, H Priddle, AJ Thomson, D Wojtacha… - Stem Cells, 2007 - academic.oup.com
Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this
capacity is lost after differentiation, and hESCs are being widely investigated for applications …

Organized development from human embryonic stem cells after injection into immunodeficient mice

K Gertow, S Wolbank, B Rozell, R Sugars… - Stem cells and …, 2004 - liebertpub.com
Information concerning the development and differentiation of human embryonic stem (hES)
cells in vivo is limited. The present study has focused on the in vivo outcome and …

Development of a decoy immunization strategy to identify cell-surface molecules expressed on undifferentiated human embryonic stem cells

HS Choi, H Kim, A Won, JJ Kim, CY Son, KS Kim… - Cell and Tissue …, 2008 - Springer
Little is known about the cell-surface molecules that are related to the undifferentiated and
pluripotent state of human embryonic stem cells (hESCs). Here, we generated a panel of …

Derivation of human embryonic stem cells in xeno-free conditions

MC Vemuri, T Schimmel, P Colls, S Munne, J Cohen - Stem Cell Assays, 2007 - Springer
Human embryonic stem cells (hESC) have the potential to treat a wide range of diseases.
Currently, the use of existing hESC lines in human clinical applications is limited, as they are …

[HTML][HTML] Expression of the Clustered NeuAcα2–3Galβ O-Glycan Determines the Cell Differentiation State of the Cells

K Higashi, K Asano, M Yagi, K Yamada… - Journal of Biological …, 2014 - ASBMB
Human embryonic stem cells (hESCs) are pluripotent stem cells from early embryos, and
their self-renewal capacity depends on the sustained expression of hESC-specific …

Derivation of human embryonic stem cells by immunosurgery

AE Chen, DA Melton - JoVE (Journal of Visualized Experiments), 2007 - jove.com
The ability of human embryonic stem cells to self-renew and differentiate into all cell types of
the body suggests that they hold great promise for both medical applications and as a …

Anti-human embryonic stem cell monoclonal antibody Hesca-2 binds to a glycan epitope commonly found on carcinomas

MG Shoreibah, CL Jackson, PW Price… - Stem Cells and …, 2011 - liebertpub.com
Hesca-2, a monoclonal antibody (mAb) IgM raised to the human embryonic stem cell (hESC)
line BG-01v, binds with high affinity (nM) to the disaccharide epitope (Galβ1-3GlcNAc) on a …

Selective removal of undifferentiated human embryonic stem cells using magnetic activated cell sorting followed by a cytotoxic antibody

K Schriebl, G Satianegara, A Hwang… - … Engineering Part A, 2012 - liebertpub.com
One of the most pertinent concerns of using differentiated cells derived from human
embryonic stem cells (hESC) is the presence of residual undifferentiated hESC, because …

Therapeutic applications of embryonic stem cells

Y Shufaro, BE Reubinoff - Best Practice & Research Clinical Obstetrics & …, 2004 - Elsevier
Embryonic stem (ES) cells have the potential to proliferate indefinitely in culture and can
differentiate into any cell type. The emergence of ES cell lines from human embryos in the …

Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings

KH Grinnemo, M Kumagai-Braesch… - Reproductive …, 2006 - Elsevier
Recent studies have suggested that human embryonic stem cells (HESC) are immune-
privileged and may thereby circumvent rejection. The expression of immunologically active …