Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma
treatment. However, acquired TMZ resistance represents a major clinical challenge that …

We aimed to explore the mechanism of the KCNQ 1 OT 1/miR‐760/PPP 1R1B axis acting to
regulate methotrexate (MTX) resistance of colorectal cancer (CRC). Differentially expressed …

Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and
maxillofacial region, severely affects human health. However, current treatments for OSCC …

Glioblastoma (GBM) is the most malignant primary tumor in the central nervous system of
adults. Temozolomide (TMZ), an alkylating agent, is the first-line chemotherapeutic agent for …

Understanding of the microRNAs (miRNAs) regulatory system has become indispensable
for physiological/oncological research. Tissue and organ specificities are key features of …

Purpose Pyruvate kinase isoenzyme M2 (PKM2) is a key enzyme in aerobic glycolysis;
inhibition of PKM2 leads to the tumor growth inhibition. In this study, the effects of combined …

Simple Summary Glioblastoma is the most prevalent and lethal brain tumor type, often
treated with the DNA alkylating agent temozolomide (TMZ). The cytotoxic DNA lesion O6 …

Background: Glioblastoma (GB) is one of the most common (~ 30%) and lethal cancers of
the central nervous system. Although new therapies are emerging, chemoresistance to …

Background Glioblastoma multiforme (GBM), the most aggressive malignant primary brain
tumor of the central nervous system, is characterized by a relentless disease recurrence …

Background Recent findings around long noncoding RNAs (lncRNAs) have opened novel
areas of research around their prospective use in overcoming chemoresistance. Herein, we …