Objective: The aim was to investigate the involvement of polyamines in the development of
cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension. Methods …

Biochemical mechanisms which control cardiac and vascular response to hypertension are
still unclear. Modifications of polyamines (putrescine, spermine, spermidine) may play a role …

Objective: To investigate whether angiotensin II (Ang II) exerts a direct effect on
cardiovascular hypertrophy in the spontaneously hypertensive rat or acts indirectly through …

Endogenous polyamines play a key role in mediating cellular growth and differentiation.
Hypertension is associated with structural modifications of the circulatory system, a process …

This experiment was designed to determine how the angiotensin-converting enzyme
inhibitor, lisinopril, acts on left ventricular wall stress and cardiac polyamine concentrations …

抄録 It is well known that isoproterenol (ISO) a nonselective β adrenoceptor agonist induces
cardiac hypertrophy. It can be assumed that, in addition to its direct cardiac effect, ISO has a …

While a number of factors may initiate structural alterations within the cardiovascular system
in response to hypertension, there are obligate cellular signaling mechanisms, such as the …

The objective of this study was to determine the relative importance of angiotensin II (Ang II)
and aldosterone in cardiovascular hypertrophy. Rats were given an infusion of Ang II (200 …

Vascular structural changes in hypertension are proposed to contribute to raised peripheral
resistance. Endogenous polyamines (putrescine, spermidine and spermine) have an …

Angiotensin II (Ang II) may cause cardiovascular hypertrophy as a consequence of
increased blood pressure or possibly by direct trophic actions. To dissociate Ang II and …