Somatic mutations are an unavoidable consequence of aging tissues. Even though most
mutations are functionally silent, some may affect genes critical to proper tissue self-renewal …

Stably acquired mutations in hematopoietic cells represent substrates of selection that may
lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with …

Acquired genetic mutations in hematopoietic stem or progenitor cells can lead to clonal
expansion and imbalanced blood cell production. Clonal hematopoiesis is exceptionally …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Recent genomics studies have revealed that clonal hematopoietic expansion due to
recurrent somatic mutations in hematopoietic cells are common in older people without …

Age is the most important risk factor for cardiovascular disease and appears to be more than
a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension …

Myeloid malignancies, including myelodysplastic syndromes (MDS), polycythemia vera,
primary myelofibrosis, and acute myeloid leukemia (AML), have a male predominance. 1–4 …

Background Recent evidence suggests that age-related clonal hematopoiesis (CH) might
represent the earliest precursor of myeloid neoplasms. Although the exact mechanism of …

Hematol Oncol Clin N Am 34 (2020) 357–367 https://doi. org/10.1016/j. hoc. 2019.11. 006
hemonc. theclinics. com 0889-8588/20/© 2019 Elsevier Inc. All rights reserved. phenotype …