The understanding of clonal hematopoiesis (CH) and its features is rapidly evolving in step
with the spread of sequencing techniques. Indeed, CH detection is now an emerging aspect …

Abstract Purpose of Review The purpose of this review article is to summarize the preclinical
and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate …

Clonal hematopoiesis (CH)–a biological state in which one or a small number of
hematopoietic stem or progenitor cells contribute disproportionately to blood cell production …

Clonally restricted hematopoiesis is a common aging-associated biological state that
predisposes to subsequent development of a hematological malignancy or cardiovascular …

Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank
identified 10 new loci associated with the development of clonal hematopoiesis and …

Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic
malignancy. There are still significant knowledge gaps in identifying high-risk patients with …

Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones
caused by the acquisition of somatic point mutations or mosaic chromosomal alterations …

Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of
progressing to hematologic malignancies. CH mutations are predominantly found in aged …

Mutation accumulation during life can contribute to hematopoietic dysfunction; however, the
underlying dynamics are unknown. Somatic mutations in blood progenitors can provide …

With age, acquired mutations can cause clonal expansion of hematopoietic stem cells
(HSC). This clonal hematopoiesis of indeterminate potential (CHIP) leads to an increased …