Senegenin rescues PC12 cells with oxidative damage through inhibition of ferroptosis

H Zhang, W Zhou, J Li, Z Qiu, X Wang, H Xu… - Molecular …, 2022 - Springer
Oxidative stress is one of the pathological mechanisms of Alzheimer's disease (AD), and
ferroptosis has been determined to be involved in neurodegenerative diseases such as AD …

Salidroside ameliorates mitochondria‐dependent neuronal apoptosis after spinal cord ischemia‐reperfusion injury partially through inhibiting oxidative stress and …

C Gu, L Li, Y Huang, D Qian, W Liu… - Oxidative medicine …, 2020 - Wiley Online Library
Ischemia‐reperfusion injury is the second most common injury of the spinal cord and has the
risk of neurological dysfunction and paralysis, which can seriously affect patient quality of …

[HTML][HTML] Gastrodin ameliorates cognitive dysfunction in vascular dementia rats by suppressing ferroptosis via the regulation of the Nrf2/Keap1-GPx4 signaling pathway

Y Li, E Zhang, H Yang, Y Chen, L Tao, Y Xu, T Chen… - Molecules, 2022 - mdpi.com
Gastrodia elata Bl. has a long edible history and is considered an important functional food
raw material. Gastrodin (GAS) is one of the main functional substances in G. elata BI. and …

[HTML][HTML] Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury

J Liu, C Huang, J Liu, C Meng, Q Gu, X Du… - Pharmacological …, 2023 - Elsevier
Ferroptosis has been implicated in the pathophysiological progression of a variety of
diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular …

The 5-lipoxygenase inhibitor zileuton confers neuroprotection against glutamate oxidative damage by inhibiting ferroptosis

Y Liu, W Wang, Y Li, Y Xiao, J Cheng… - Biological and …, 2015 - jstage.jst.go.jp
Lipoxygenase (5-LOX) inhibitors have been shown to be protective in several
neurodegenerative disease models; however, the underlying mechanisms remain unclear …

Ferroptosis is involved in the development of neuropathic pain and allodynia

H Wang, X Huo, C Han, J Ning, H Chen, B Li… - Molecular and Cellular …, 2021 - Springer
Neuropathic pain (NP) is chronic, intractable, and typically not alleviated using analgesics.
Ferroptosis is a new type of cell death characterized by mitochondrial damage, oxidative …

[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury

F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …

[HTML][HTML] Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

X Wang, X Chen, W Zhou, H Men, T Bao, Y Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy
(DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a …

[HTML][HTML] Role and mechanism of ferroptosis in neurological diseases

M Ou, Y Jiang, Y Ji, Q Zhou, Z Du, H Zhu, Z Zhou - Molecular Metabolism, 2022 - Elsevier
Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

Lipoxin A4 protects primary spinal cord neurons from Erastin‐induced ferroptosis by activating the Akt/Nrf2/HO‐1 signaling pathway

N Wei, T Lu, L Yang, Y Dong, X Liu - FEBS open bio, 2021 - Wiley Online Library
Ferroptosis is an iron‐dependent programmed cell death, which participates in the
pathogenesis of spinal cord injury (SCI). Our previous study has revealed that Lipoxin A4 …