These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …

Objective: TGF-β stimulation of cardiac myocytes induces a hypertrophic responsiveness to
β-adrenoceptor stimulation. This study investigates whether this β-adrenoceptor mediated …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …

DFMO is a selective irreversible inhibitor of ornithine decarboxylase (ODC), the initial
enzyme in the polyamine biosynthetic pathway. DFMO was utilized to determine the role of …

Ornithine decarboxylase, a possible rate-limiting enzyme in the synthesis of polyamines,
was assayed in hearts of normal rats, sham-operated rats, and rats subjected to aortic …

The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme involved in the
biosynthesis of polyamines, is markedly elevated in the adult rat heart 4 hr after …

The present study was designed to provide a better understanding of the role played by
AdoMetDC (S-adenosylmethionine decarboxylase), the key rate-controlling enzyme in the …

Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines,
displays high activity early in postnatal development of the heart, followed by a gradual …

The responses of AMP-activated protein kinase (AMPK) and Ornithine decarboxylase (ODC)
to isoproterenol have been examined in H9c2 cardiomyoblasts, AMPK represents the link …

Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …