Engineering exosomes for cancer therapy

KE Gilligan, RM Dwyer - International journal of molecular sciences, 2017 - mdpi.com
There remains an urgent need for novel therapeutic strategies to treat metastatic cancer,
which results in over 8 million deaths annually worldwide. Following secretion, exosomes …

Exosomes: cell-derived nanoplatforms for the delivery of cancer therapeutics

H Kim, EH Kim, G Kwak, SG Chi, SH Kim… - International journal of …, 2020 - mdpi.com
Exosomes are cell-secreted nanovesicles that naturally contain biomolecular cargoes such
as lipids, proteins, and nucleic acids. Exosomes mediate intercellular communication …

Exosome as a delivery vehicle for cancer therapy

B Moon, S Chang - Cells, 2022 - mdpi.com
Exosomes are small extracellular vesicles that are naturally produced and carry
biomolecules such as proteins, microRNAs, and metabolites. Because of their small size …

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer

A Srivastava, A Babu, J Filant… - Journal of …, 2016 - ingentaconnect.com
The bottleneck in current vector-based cancer therapy is the targeted and controlled release
of therapeutics in tumors. Exosomes are submicron-sized vesicles that are secreted by all …

Exosomes in cancer development and clinical applications

YL Tai, KC Chen, JT Hsieh, TL Shen - Cancer science, 2018 - Wiley Online Library
Exosomes participate in cancer progression and metastasis by transferring bioactive
molecules between cancer and various cells in the local and distant microenvironments …

Recent advances in exosome-based drug delivery for cancer therapy

H Kim, H Jang, H Cho, J Choi, KY Hwang, Y Choi… - Cancers, 2021 - mdpi.com
Simple Summary Exosomes derived from various sources can deliver therapeutic agents
such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

[HTML][HTML] New advances in exosome-based targeted drug delivery systems

D Ferreira, JN Moreira, LR Rodrigues - Critical Reviews in Oncology …, 2022 - Elsevier
In recent years, various drug nano-delivery platforms have emerged to enhance drug
effectiveness in cancer treatment. However, their successful translation to clinics have been …

[HTML][HTML] A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

J Li, Y Zhang, PY Dong, GM Yang… - Biomedicine & …, 2023 - Elsevier
All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

Engineering of exosomes to target cancer metastasis

Z Zhang, JA Dombroski, MR King - Cellular and Molecular Bioengineering, 2020 - Springer
As a nanoscale subset of extracellular vehicles, exosomes represent a new pathway of
intercellular communication by delivering cargos such as proteins and nucleic acids to …