ABSTRACT Vitamin B-12 (cobalamin) deficiency results in decreased L-methylmalonyl-
coenzyme A (CoA) mutase activity. The consequence of this defect on the cellular CoA pool …

The aim of the present study was to examine the effects of cobalamin (Cbl) on the activity
and expression of l-methylmalonyl-CoA mutase (MCM) in rat liver and cultured COS-7 cells …

Treatment of rats with the vitamin B12 analogue hydroxy-cobalamin [c-lactam](HCCL)
impairs methylmalonyl-CoA mutase function and leads to methylmalonic aciduria due to …

The amount of methylmalonate (MMA) excreted in the urine by rats maintained on vitamin B
12-deficient diets was found to be a useful indicator of the severity of B 12 deficiency. MMA …

The administration in vivo of the cobalamin analogue hydroxycobalamin [c-lactam] inhibits
hepatic L-methylmalonyl-CoA mutase activity. The current studies characterize in vivo and in …

Vitamin B 12-coenzyme levels have been measured in the liver, kidney, and brain of normal
and vitamin B 12-deficient rats, and in the liver, kidney, and heart of deficient and …

In vitamin B-12 (cobalamin) deficiency the metabolism of propionyl-CoA and methylmalonyl-
CoA are inhibited secondarily to decreased L-methylmalonyl-CoA mutase activity …

The in vivo coenzyme A intermediates involved in the metabolic pathway in which vitamin B
12 serves as a coenzyme (conversion of methylmalonyl-CoA to succinyl-CoA) were …

Lambs (3 months of age) and ewes were fed ad libitum a depletion diet low in cobalt (0.06
ppm) for 7 months. Five sheep were then assigned to each of the following treatments: 330 …

Vitamin-B12-deficient rats were bred from depleted dams and maintained on a diet of grain
and yeast. The control rats had that diet supplemented with vitamin B12, 15 µg. per 100 g …