Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

During the growth of various cancers, primary tumors can escape antitumor immune
responses of their host and eventually disseminate into distant organs. Peritumoral …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …

Lymph node metastases occur frequently during the progression of many types of cancer,
and their presence often reflects poor prognosis. The drainage of tumor-derived factors such …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-
tumor T-cell immune response. However, cancer-derived immune suppressive factors …

Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role
in cancer progression is still not completely understood. Emerging evidence suggests that …

Lymph nodes that lie immediately downstream of tumors [tumor‐draining lymph nodes
(TDLNs)] undergo profound alterations due to the presence of the upstream tumor. The …

The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in
many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the …