Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …

Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …

Loss of the Y‐chromosome (LOY) is described as both a normal age‐related event and a
marker of a neoplastic clone in hematologic diseases. To assess the significance of LOY in …

Context.—The clinical association between loss of the Y chromosome and acute
myelogenous leukemia and myelodysplastic syndrome (AML/MDS) has been debated …

To further investigate the potential clinical significance of Y chromosome loss as the sole
bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or …

Isolate loss of chromosome Y (-Y) in myelodysplastic syndromes (MDS) is associated to a
better outcome but it is also well described as an age-related phenomenon. In this study we …

We have studied 215 male patients (aged 45–97 years) whose sole cytogenetic abnormality
was clonal loss of the Y chromosome in metaphase cells from unstimulated cultures. The …

Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …