The F11 hybridoma, a dorsal root ganglion-derived cell line, was used to investigate the
response of nociceptive sensory neurons to nanotopographical guidance cues. This …

Tissue engineering provides a valuable tool for in vitro investigation of complex in vivo
environments. A particular application of tissue-engineered in vitro platforms in …

Despite major advances in the pathophysiological understanding of peripheral nerve
damage, the treatment of nerve injuries still remains an unmet medical need. Nerve …

We employ simple geometrical rules to design a set of nanotopographies able to interfere
with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint …

During development and regeneration of the mammalian nervous system, directional
signals guide differentiating neurons toward their targets. Soluble neurotrophic molecules …

Stem cells display sensitivity to substrate presentation of topographical cues via changes in
cell morphology. These biomechanical responses may be transmitted to the nucleus through …

In order for cells to react to topography, they must be able to sense shape. When
considering nano-topography, these shapes are much smaller than the cell, but still strong …

Nanotechnology has provided methods to fabricate surface patterns with features down to a
few nm. If cells or cell processes exhibit contact guidance in response to such small patterns …

Controlling neuronal cell adhesion, migration, and axonal outgrowth via contact interactions
with biomaterials is a critical element for tissue engineering applications and for developing …

The interaction of murine embryonic cortical neurons on randomly orientated electrospun
scaffolds of poly (L-lactide)(PL LA) and poly (lactide-co-glycolide)(PLGA) is investigated in …