Chromosomal abnormalities provide clinical utility in the diagnosis and treatment of
hematologic malignancies, and may be predictive of malignant transformation in individuals …

Ample evidence exists for shared risk factors for genetic mosaicism and cancer risk as well
as abundant support linking genetic mosaicism in leukocytes to hematologic malignancies …

We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

Human genetic mosaicism is the presence of two or more cellular populations with distinct
genotypes in an individual who developed from a single fertilized ovum. While initially …

The occasional observation of constitutional chromosomal abnormalities in patients with a
malignant disease has led to a number of studies on their potential role in cancer …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …

The present study was undertaken to ascertain the frequency of cytogenetic polyclonality in
various hematologic malignancies and to investigate whether morphologic subgroup, age …

Large copy-number variants (CNVs) are strongly associated with both developmental delay
and cancer, but the type of disease depends strongly on when and where the mutation …

Monosomal karyotype (MK) has recently been associated with poor prognosis in acute
myeloid leukemia (AML), myelodysplastic syndromes (MDS), and primary myelofibrosis …

Detectable clonal mosaicism for large chromosomal events has been associated with aging
and an increased risk of hematological and some solid cancers. We hypothesized that …